Organotypic Intestinal Culture and Cranial Cervical Ganglion Culture Challenges

The aim of thisĀ Organotypic and Ganglion Cell Culture study was to develop an organotypic intestinal or ganglion culture which could be used as an in vitro model to investigate whether Clostridium botulinum neurotoxins can induce the enteric neuronal pathology that characterises EGS, thereby confirming or refuting the hypothesis that these toxins cause EGS.

Cellculture~2

Neurons showing normal morphology in the myenteric plexus of sheep ileum (small intestines)