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Molecular signatures of the activity of clostridial toxins in EGS

This project aimed to search for evidence that the neurodegeneration seen in EGS is attributable to the action of Clostridium botulinum Type C toxins using proteomic methods. Unfortunately, given the methodological problems encountered, and in particular the inexplicable absence of a detectable positive control for this analysis it was considered not possible to publish this study. This report is available for reference.

Molecular signatures report

27/2/2013

• EGSF Five Year Research Plan
• Equine Grass Sickness: A research update and look to the future
• Reporting Grass Sickness Cases
• Results of a nationwide field trial for a vaccine for the prevention of equine grass sickness
• Residual Lesions Study
• Fusarium Study
• Characterising the Metabolic and Microbiological Disturbances Induced by Equine Grass Sickness
• Proteomic study sheds light on neurodegeneration in grass sickness
• Pilot Field Vaccine Trial for Equine Grass Sickness
• Vaccine Field Trial
• EGS Research Grant Application
• Evaluation of an Enteral Feeding System for Chronic Grass Sickness Patients
• Evaluation of Synaptophysin as an immunohistochemical marker for Equine Grass Sickness
• Grass Sickness Research References
• Potential management practices which may reduce the risk of grass sickness
• Organotypic Intestinal Culture and Cranial Cervical Ganglion Culture Challenges
• Molecular signatures of the activity of clostridial toxins in EGS
• Analysis of Proteins in Urine
• Equine Grass Sickness Indican Study
• Ouchterlony Double Immunodiffusion Method and Equine Grass Sickness
• Prevalence of Clostridium perfringens in faeces and ileal contents from grass sickness affected horses
• Grass Sickness and Botulism
• Phenylephrine Eyedrops as a Diagnostic Test in Grass Sickness
• Role of Clostridium botulinum in EGS
• Residual Damage in Treated Cases of Grass Sickness
• Results of an epidemiological study of recurrence of equine grass sickness on affected premises
• Can urine testing aid the early diagnosis of Grass Sickness?
• Detection of Specific Antibodies to Clostridium Botulinum Type C in the Colostrum and Milk of Mares
• A comparative study of the bacteriology of the GI tract of horses